{"id":2234,"date":"2017-08-24T18:03:15","date_gmt":"2017-08-24T12:33:15","guid":{"rendered":"https:\/\/healthool.com\/?p=2234"},"modified":"2022-01-12T13:16:32","modified_gmt":"2022-01-12T07:46:32","slug":"osteogenesis-imperfecta-type-iv","status":"publish","type":"post","link":"https:\/\/healthool.com\/osteogenesis-imperfecta-type-iv\/","title":{"rendered":"Osteogenesis Imperfecta Type IV"},"content":{"rendered":"

Osteogenesis imperfecta is a form of genetic disease in which the bone of the patient breaks easily. For this reason, Osteogenesis imperfecta is called brittle bone disease. It is associated with a malfunctioning of one of the genes that make protein (type 1 collagen).<\/p>\n

This protein is a primary component of the connective tissues in the bones. It also aids in the formation of ligaments, white outer tissue of the eyeballs, and teeth<\/a>. Because of the defective gene, the production of type 1 collagen is impaired. This has resulted to weak bones that tend to break easily. (1, 2<\/strong>)<\/sup><\/p>\n

\"An<\/p>\n

Image 1: An image comparison of a healthy bone and a bone with osteogenesis imperfecta\/brittle bone disease.
\nPhoto Source: ghr.nlm.nih.gov<\/p>\n

\"A<\/p>\n

Photo 3: A clinical manifestation of a female patient with osteogenesis imperfecta.<\/p>\n

Is it a genetic disease?<\/h3>\n

Most cases of Osteogenesis imperfecta is caused by a defective gene from any of the parents. There are instances though when none of the parents have OI. The reason for OI is spontaneous mutation of the gene. It came to a point when the gene is no longer functioning correctly. (2<\/strong>)<\/sup><\/p>\n

What are the clinical manifestations?<\/h3>\n