Home » Diseases and Conditions » Anisocytosis


Last reviewed by Dr. Raj MD on January 12th, 2022.

What is Anisocytosis?

Anisocytosis refers to the size of the red blood cells wherein it is found to have a variation in size rather than the normal and standard size based on the parameter in measuring the red blood cell size and red blood cell volume. The parameter used to measure the size and volume in red blood cell is known as red cell distribution width which is calculated by dividing the red blood cell volumes from mean corpuscular volume or MCV.

Anisocytosis is a medical condition involving the red blood cells and is commonly found in people suffering from Anemia and any other blood disorders and conditions including Thalassemia.

Symptoms of Anisocytosis

Anisocytosis manifests in various symptoms although the characteristic manifestation of anisocytosis is influenced by the oxygen supply in the body which is carried insufficiently.

Breathlessness is usually experienced by patients suffering from anisocytosis even with minimal activities and which may be experienced often.

Pale skin is especially seen in nail beds and eyeballs including other areas of the skin. The paleness is relative to insufficiency in oxygen supply distributed to the tissue of the body.

Tiredness and exhaustion are the remarkable characteristic of anisocytosis in people suffering from it. Patient easily gets tired and lacks in energy to go about daily activities or even finish a task.

Rapid heartbeat is experienced even in the absence of a rigid activity that can trigger fast heart beats. Often, rapid heartbeat is related to experience of tiredness and exhaustion.

The symptoms manifested are reflection of inefficiency in oxygen distribution as influenced by variation in the size of red blood cells while most of the symptoms are similar to the symptoms of anemia or heart failure. It is therefore necessary to seek medical attention for prompt treatment.


Anisocytosis arises from various factors involving the red blood cells that in effect, influenced the variation in the size of the red blood cells or irregularity in the measurement of the RBC.

Medical condition of anemia is primarily indicated to result in the production of red blood cell in various sizes. Other variation of anemia can also affect the production of red blood cells bringing insufficiency as a result. Congenital anemia and thalassemia are among the medical condition that can result to production of abnormal size of red blood cells. A condition of insufficiency in the production of red blood cells involving the bone marrow also results to anisocytosis and this condition is known as Diamond-Blackfan syndrome.

Vitamin deficiency also affects the production of red blood cells and its size. Vitamin A and Vitamin B12 are essential components in the production of RBC that a deficiency in any or both of these vitamins can lead to anisocytosis.

Blood transfusion is another factor that can result to anisocytosis. The condition is temporary and the onset is due to transfused blood which may be of different size from that of the recipient.


Anisocytosis is not a disease that no treatment is indicated to cure it. The goal of treatment is intended towards the underlying condition that influences the onset of anisocytosis including the relief of symptoms. The mode of treatment depends on the varying condition as the manifestation and existing condition differ from one person to another.

Leave a Reply

© 2022 Healthool.com. All Rights Reserved. Privacy Policy. About Us | Contact Us
The health information provided on this web site is for educational purposes only and is not to be used as a substitute for medical advice, diagnosis or treatment.